RFA: IDDRC MIR Scanning Pilots

The Washington University Intellectual and Developmental Disabilities Research Center (IDDRC@WUSTL) is now accepting applications for imaging-focused pilot proposals that will test bold new hypotheses in IDD research and will generate critical proof-of-concept data necessary for securing larger federally funded awards. Previous IDDRC pilot awardees are eligible and encouraged to apply if the use of scanning funds would further develop their pilot research. Projects may be awarded funds ranging from $15,000 to $20,000 from the following sources:

Applications are due by January 30, 2024

Applicants should submit the following:

  • Name(s) of Principal investigator(s) and proposed project title
  • Specific Aims page (NIH-format)
  • 300-word statement describing how the investigator would use immediate pilot funding to generate pilot data for a full application.
  • Budget and budget justification

The proposal must address one or more of the four research themes of the IDDRC@WUSTL

THEMECRITICAL RELIANCE ON IDDRC SCIENTIFIC CORES (partial listing)
IELUCIDATION OF INTERMEDIATE PHENOTYPES: Core neurobehavioral features of IDDs that clarify causal origins, trace familial transmission, and index response-to-intervention.MSCCross-species studies of behavioral deficits in IDD
DNCRelate behavioral endophenotypes to neural signatures
CTCState-of-the-art developmental and behavioral assessment and phenotyping technologies; genotype-phenotype correlation, D/I
IICHARACTERIZATION OF THE DEVELOPING BRAIN: Identification of neural signatures to elucidate mechanisms of disability at the level of whole brain or circuit and contribution to the discovery of high-specificity biomarkers.MSCNeuropathology of rodent models of IDD
DNCLongitudinal imaging of infants at risk for IDD
CTCComprehensive behavioral phenotyping to establish relationships between neuroimaging and neurobehavioral manifestations of IDD, D/I of biomarkers
IIIFUNCTIONAL GENOMICS FOR DISCOVERY OF CONVERGENT PATHOGENIC MECHANISMS:  Elucidation of pathways shared by diverse causes of IDD, to inform novel therapeutic targets for the largest possible number of patients.MSCAnimal and cellular models of monogenic DD syndromes
DNCImaging of genetic sub groups, incl. severe IDD syndromes
CTCIdentifying functional homologies across DD sub groups defined by clinical characteristics ascertained via behavioral and genomic characterization
IVTAILORING INTERVENTION TO SPECIFIC GENETIC AND ENVIRONMENTAL INSULTS TO THE DEVELOPING BRAIN: Harnessing genomic information and new insights on pathogenic mechanisms for personalized intervention.MSCRescue experiments involving manipulation of the genome
DNCIdentification of early neural signatures of DD risk that trigger presymptomatic intervention
CTCBuilding infrastructure for IDD-specific clinical trials
MSC: Model Systems Core; DNC: Developmental Neuroimaging Core; CTC: Clinical Translation Core; D/I: Dissemination/Implementation
Restrictions:  An investigator may only have one active Mallinckrodt Institute of Radiology award. An investigator may only be granted one ICTS-JIT award in a 12-month period.
 
Applications should be submitted as a pdf attachment to the IDDRC@WUSTL email: iddrc@email.wustl.edu (cc: abbaccha@wustl.edu) with “IDDRC Imaging Pilot Letter of Intent” in the subject line of the email message. We will confirm receipt of your submission.
 
Additional guidance for the development of specific aims for this proposal can be provided by IDDRC@WUSTL scientific liaisons Drs. Tychele Turner (tychele@wustl.edu) and Jeffrey Neil (neil@wustl.edu), as well as Center leadership (core and unit directors). 
 
Administrative Support:  Program Manager, Anna Abbacchi (abbaccha@wustl.edu); Grants Specialist, Diane Robison (robisond@wustl.edu).
Becoming a Member

Eligibility

Eligibility is open to any Washington University faculty member engaged in research of relevance to intellectual and developmental disabilities. This includes Principal Investigators and Co-Investigators. Graduate students and post-doctoral scholars are encouraged to access IDDRC resources through primary IDDRC investigators/mentors.

Benefits of an IDDRC Membership

  • Access to IDDRC Core Services
  • Eligibility for IDDRC pilot funds
  • Continuous exchange of news, ideas,
  • Access to education and advancement opportunities
  • Ability to present research and findings through IDDRC-sponsored lectures, symposia, and seminars

Obligations of an IDDRC Member

  • Conduct research in accordance with IDDRC mission statement
  • Utilize proper IDDRC NIH citation (NIH/NICHD P50 HD103525) for publications benefiting from Core Services
  • Contribute to scientific dialogue through IDDRC lectures, symposia, communications, and seminars
  • Report progress regularly on research activities, grants, and publications relating to IDDRC-supported projects

To apply for Membership

Please submit the following to iddrc@email.wustl.edu

  • Biosketch/CV
  • Name, Title, Department
  • Several sentences about how your interests could be leveraged for the success of the IDDRC and/or how we can help your career

List of Current Members
  • Agner, Shannon
  • Ances, Beau
  • Anokhin, Andrey
  • Arbelaez, Ana Maria
  • Baldridge, Dustin
  • Barch, Deanna
  • Bayly, Philip
  • Black, Kevin
  • Botteron, Kelly
  • Brestoff, Jonathon
  • Buchser, William
  • Cashikar, Anil
  • Cho, Jaehyung
  • Cole, F. Sessions
  • Culver, Joseph
  • Dickson, Patricia
  • Dosenbach, Nico
  • Dougherty, Joe
  • Egervari, Gabor
  • Eggebrecht, Adam
  • England, Sarah
  • Farber, Nuri
  • Fields, Melanie
  • Foutz, Tom
  • Friess, Stuart
  • Gabel, Harrison
  • Galindo, Rafael
  • Garbow, Joel
  • Glaser, Paul
  • Goodhill, Geoffrey
  • Guerriero, Rejean
  • Guilliams, Kristin
  • Gurnett, Christina
  • Gutmann, David
  • Hengen, Keith
  • Hershey, Tamara
  • Herzog, Erik
  • Holtzman, David
  • Hoyt, Catherine
  • Huettner, James
  • Imai, Shin-Ichiro
  • Kelly, Jeannie
  • Kepecs, Adam
  • Klein, Robyn
  • Klyachko, Vitaly
  • Kravitz, Alexxai
  • Kroll, Kristen
  • Lang, Catherine
  • Lean, Rachel
  • Lee, Jin-Moo
  • Luby, Joan
  • Maloney, Susan
  • Mamah, Daniel
  • Marcus, Daniel
  • Markson, Lori
  • Marrus, Natasha
  • Mennerick, Steven
  • Milbrandt, Jeffrey
  • Mitra, Robi
  • Morris, Stephanie
  • Neil, Jeffrey
  • Nicol, Ginger
  • Noguchi, Kevin
  • O’Malley, Karen
  • Ortinau, Cynthia
  • Perkins, Stephanie
  • Perlman, Susan
  • Pruett, John
  • Reiersen, Angela
  • Reynolds, Margaret
  • Richards, Linda
  • Rogers, Cynthia
  • Rubin, Josh
  • Ryther, Robin
  • Sands, Mark
  • Schechtman, Ken
  • Schwartz, Alan
  • Shimony, Joshua
  • Shinawi, Marwan
  • Skeath, James
  • Smith, Alyssa
  • Smyser, Chris
  • Snyder, Avi
  • Snyder, Lawrence
  • Solnica-Krezel, Lila
  • Song, Sheng-Kwei
  • Stout, Molly
  • Sylvester, Chad
  • Thio, Liu Lin
  • Turner, Ashley
  • Turner, Tychele
  • Urano, Fumihiko
  • Vesoulis, Zachary
  • Wang, Shuo
  • Wang, Yong
  • Wen, Jie
  • White, Michael A
  • Wong, Michael
  • Wozniak, David
  • Yi, Jason
  • Yuede, Carla
  • Zorumski, Charles

Publication Submission and Acknowledging the IDDRC

If you utilized the IDDRC resources, please ensure you properly acknowledge the IDDRC’s NIH Grant (P50 HD103525). You can use the following suggested language:

Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number P50 HD103525 to the Intellectual and Developmental Disabilities Research Center at Washington University. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

The McDonnell Center for Systems Neurosciences asks to be acknowledged in any publication or presentation resulting from Center funding. Please use the following language in the Acknowledgements section of publications to describe work supported by Center funds:

“This work was supported by funds provided by the McDonnell Center for Systems Neuroscience at Washington University in St. Louis.”

All papers must conform to NIH’s Open Access Policy, meaning that the paper must be submitted through the NIHMS. Papers that are fully compliant are issued a PMCID number (different from a PubMed ID). Some journals will automatically complete this process for you, but others do not and will require you manually upload the manuscript via NIHMS. WUSM’s Becker Library maintains an excellent resource page with instructions and information to understand the process.

When your paper is published, be sure to notify the IDDRC via iddrc@email.wustl.edu and the Directors of the IDDRC cores you utilized so we can ensure that your important work is counted in the work of the IDDRC.