Model Systems Core
Impact of Model Systems on IDD Research
Animal and cellular models are revolutionizing our understanding of countless human disorders including intellectual and developmental disabilities (IDD). Such models provide fundamental insights into biological pathways and often display phenotypes that are similar to clinical indicators of the human disease or provide key insights into pathogenic mechanisms, including those that converge across disparate causal influences on IDD. Thus, animal and cellular models provide critical opportunities to identify novel targets for intervention and therefore the development of new preventive interventions and therapies. Towards this end, the overall goal of the Model Systems Core (MSC) is to seamlessly provide expertise, resources, and assessment services to WU investigators involved in the creation and evaluation of animal and cellular models of IDD.
To do so, we draw on our institutional strengths in genetics, brain imaging, bioinformatics, developmental biology and neuroscience to provide consultation, support, and specific services to WU investigators involved in understanding and treating IDD. Through these activities the MSC will inform clinical approaches to higher-impact intervention in IDD and provide access to models and techniques that can encourage scientists to expand their efforts along the lines of the primary research themes of the IDDRC@WUSTL.