The mission of the IDDRC@WUSTL is to implement cutting-edge innovations in science for the discovery of new, higher impact interventions for all individuals with developmental disabilities.

The IDDRC@WUSTL synthesizes faculty and institutional resources across a variety of disciplines at Washington University as well as collaborations with other universities and IDDRC's across the nation. The IDDRC is composed of 3 scientific Cores (see diagram below) which each have specific aims related to the field of Intellectual and Developmental Disability research. Two Faculty Navigators are available to assist WUSTL faculty in understanding and accessing services through each Core while also promoting and developing new lines of research.

Director of the IDDRC@WUSTL

John N. Constantino, MD
Blanche F. Ittlesson Professor of Psychiatry

Core Research Themes

  1. The prediction and prevention of preterm birth
  2. Elucidation of core elements of risk and resilience for IDD
  3. Characterization of the developing human brain
  4. Understanding cellular and molecular mechanisms of genetic risk for IDD

Aims of the Model Systems Core

  1. To provide consultation to investigators needing assessments in animal behavior, pathology and CNS function.
  2. To characterize neurological deficits in rodent and cellular models of IDD submitted by investigators.
  3. To integrate information across units, cores and other existing facilities within the University.

Aims of the Developmental Neuroimaging Core

  1. To provide high-quality comprehensive consultation for study design
  2. To conduct highly cost-efficient data acquisition for IDDRC investigators collecting neuroimaging data in IDD research efforts
  3. To provide data processing, informatics, and analytic services that optimize the exploration and accurate interpretation of neuroimaging data in IDD research at WUSTL

Aims of the Clinical Translation Core

  1. To provide investigators with the expertise, resources, and assessment services needed to conduct comprehensive clinical, behavioral and genomic characterization of human subjects.
  2. To strategically harness services and expertise of allied WUSTL facilities that critically and cost-effectively complement the IDDRC@WUSTL scientific cores to contribute to a discovery pipeline for higher-impact intervention for individuals affected by or at risk for IDD
  3. To promote bidirectional interchange between scientific activity in the discovery of pathogenic mechanisms and the testing of novel approaches to IDD prevention and treatment in human subjects and among populations at risk